The "intuitive" feeling that he claims to develop after using it for awhile seems like it would be useful of you do a lot of reverse engineering or forensics work.
yeah perhaps I just havn't gotten the feel for it - think I've spent some 8-10 hours total playing around (more comfortable with regular hex+disasm+debug+scripts), I liked the https://github.com/letoram/senseye/wiki/Sense_MFile thing though