Like any other detection system you will always have determined adversaries that put in the work to bypass it.

But that doesn't mean you shouldn't still try to block the much larger number of less sophisticated/resourced adversaries that are using OOTB libraries and low-effort setups.

Sure, but of course since there's profit to be made defeating these systems once someone makes a program to defeat detection they'll sell it. Complicated attacks only stop simple attackers until a sophisticated attacker scripts & sells the exploit. Not that you shouldn't try, just don't expect defenses to last long-term.