Moonshots get made from time to time, however:

* Intel's iAPX "mainframe in a chip" project [1] was aimed at directly supporting HLL features,

* The Rekursiv chip project [2] was intended for an objected-oriented language,

* The Transputer was meant to support Occam [3]

and there have probably been others.

[1] http://en.wikipedia.org/wiki/Intel_iAPX_432

[2] http://en.wikipedia.org/wiki/Rekursiv

[3] http://en.wikipedia.org/wiki/Transputer